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علوم آزمایشگاهی (مقالات پژوهشی)

آلرژی به خربزه (Cucumis melo) و واکنش متقاطع آن با سایر مواد آلرژی زا

منبع: مجله علوم پایه پزشکی ایران، جلد ۶، شماره ۴، زمستان ۸۲ نویسنده: دکتر مجتبی سنکیان، دکتر عبدالرضا وارسته، نفیسه اسمعیل، ملیحه مقدم، دکتر راضیه پیشنماز، دکتر محمود محمودی خلاصه خربزه به عنوان یکی از گیاهان خانواده کوکوربیتاسه از جمله میوه هایی محسوب می گردد که باعث واکنش آلرژیک تیپ یک در برخی از افراد می شود. این واکنش معمولاًً ... ادامه مطلب »

Effects of Insulin and Ascorbic Acid on Inhibition of the Apoptosis in Hippocampus of STZ-Induced Diabetic Rats

Source: Journal of Iranian Anatomical Sciences, 2009 Author: Jafari Anarkooli I., Ph.D., Sankian M., Ph.D., Varasteh A.R., Ph.D., Haghir H., Ph.D. Abstract Background: The aim of this study was to investigate effects of insulin and ascorbic acid on rate of Caspase – ۳ activity and DNA Laddering in hippocampus of STZ-induced diabetic rats. Methods: Thirty male Wistar rats in five ... ادامه مطلب »

Type 2 Innate Lymphoid Cells: Friends or Foes—Role in Airway Allergic Inflammation and Asthma

Source: Hindawi Publishing Corporation Journal of Allergy, 2012 Author: Abbas Pishdadian, Abdol-Reza Varasteh, andMojtaba Sankian Abstract Innate-like lymphocytes (ILLs) and innate lymphoid cells (ILCs) are two newly characterized families of lymphocytes with limited and no rearranged antigen receptors, respectively. These soldiers provide a first line of defense against foreign insults by triggering a prompt innate immune response and bridging the ... ادامه مطلب »

Pistachio Allergy-Prevalence and In vitro Cross-Reactivity with Other Nuts

Source: Allergology International. 2011 Author: Reihaneh Noorbakhsh, Seyed Ali Mortazavi, Mojtaba Sankian, Fakhri Shahidi, Mohsen Tehrani, Farahzad Jabbari Azad, Fatemeh Behmanesh and AbdolReza Varasteh Abstract Background: Tree nut allergy is characterized by a high frequency of life-threatening reactions and is typically lifelong persistent. Some people with a pistachio nut allergy, which is common in the pistachio rich area of Iran, ... ادامه مطلب »

Monarch-1 Activation in Murine Macrophage Cell Line (J774 A.1) Infected with Iranian Strain of Leishmania major

Source: Iranian J Parasito, 2013 Author: A Fata, MR Mahmoudian, A Varasteh, M Sankian Abstract Background: Leishmania major is an intracellular parasite transmitted through the bite of the female phlebotomine sand flies. Leishmania major is able to escape the host immune defense and survive within macrophages. Modulation of the NF-κB (Nuclear Factor-Kappa B) activation and suppression of the pro-inflammatory cytokines ... ادامه مطلب »

Transforming growth factor β۱ −۸۶۹T/C and 915G/C− polymorphisms and risk of autism spectrum disorders

Source: Author: Mohammad Reza Khakzad, Farhad Salari, Maryam Javanbakht, Maryam Hojati, Abdolreza Varasteh , Mojtaba Sankian Abstract Transforming growth factor-β۱ (TGF-β۱) has been found to play a crucial role in early central nervous system development. Several studies have illustrated the decreased serum and brain levels of TGF-β۱ in children with autism. Two point mutations of TGF- β۱ gene in the ... ادامه مطلب »

Identification and characterisation of main allergic proteins in Vitis vinifera vitis

Source: Food and Agricultural Immunology, 2013 Author: Reza Falaka, Mojtaba Sankian, Reihaneh Noorbakhsh, Mohsen Tehrani, Mohammad Ali Assarehzadegan, Farahzad Jabbari Azad, Ahmad Abolhasani and Abdol-Reza Varasteh Abstract Background: Vitis vinifera vitis (grape) cultivar Sultana is a causative agent of oral allergy syndrome (OAS) in Iran. In this study, the IgE-reactive proteins of this cultivar were characterised. Methods: IgE-reactivity of sera ... ادامه مطلب »

The role of anti-CCD antibodies in grape allergy diagnosis

Source: Reports of Biochemistry & Molecular Biology, 2013 Author: Reza Falak, Mojtaba Sankian, Hanieh Ketabdar, Malihe Moghadam, Abdol-Reza Varasteh Abstract Background: Allergens are mostly composed of glycoprotein structures. It is believed that glycan-specific antibodies may lead to false-positive reactions in immunoassays. In this study we investigated the glycosylation state of grape allergens as well as the presence of antibodies to ... ادامه مطلب »

Molecular cloning, characterization, and expression of Cuc m 2, a major allergen in Cucumis melo

Source: Reports of Biochemistry & Molecular Biology, 2013 Author: Mojtaba Sankian, Mahmoud Mahmoudi, Abdol-Reza Varasteh Abstract Background: Several studies reported the clinical features of IgE-mediated hypersensitivity after ingestion of melon. Melon allergy is a common IgE-mediated fruit allergy in Iran. This prompted us to investigate immunochemical and molecular properties of the major allergen in melon fruit, to compare the IgE-binding ... ادامه مطلب »

Construction of a recombinant allergen-producing probiotic bacterial strain: Introduction of a new line for a live oral vaccine against Chenopodium album pollen allergy

Source: Reports of Biochemistry & Molecular Biology, 2013 Author: Leila Roozbeh Nasiraie, Farideh Tabatabaie, Mojtaba Sankian, Fakhri Shahidi, Abdolreza Varasteh Abstract Background: During the last two decades, significant advances have been made in the fields of lactococcal genetics and protein expression. Lactococcus lactis (L. lactis) is an effective vector for protein expression and can be used as an antigen delivery ... ادامه مطلب »